About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5447073
Allelic
Composition
Tg(Th-Peo1*,-EGFP)2Gcor/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice accumulate mitochondrial DNA deletion in the substantia nigra compared with wild-type mice (J:188914)
• mice accumulate mitochondrial DNA deletion in the substantia nigra compared with wild-type mice (J:188914)
• decreased proteasome activity in the midbrain (J:188914)
• decreased proteasome activity in the midbrain (J:188914)
• induced autophagy in the substantia nigra pars compacta (J:188914)
• induced autophagy in the substantia nigra pars compacta (J:188914)
• impaired basal mitochondria respiration rate in the midbrain at 1 to 3 months (J:188914)
• impaired basal mitochondria respiration rate in the midbrain at 1 to 3 months (J:188914)

nervous system
• at 16 to 17 and 22 to 23 months (J:188914)
• at 16 to 17 and 22 to 23 months (J:188914)
• through autophagy without an increase in reactive oxygen species production (J:188914)
• however, not increase in apoptosis is observed (J:188914)
• through autophagy without an increase in reactive oxygen species production (J:188914)
• however, not increase in apoptosis is observed (J:188914)

behavior/neurological
• at 23 months (J:188914)
• at 23 months (J:188914)

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease, Mitochondrial 556500 J:188914


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory