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Phenotypes Associated with This Genotype
Genotype
MGI:5447073
Allelic
Composition
Tg(Th-Twnk*,-EGFP)2Gcor/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice accumulate mitochondrial DNA deletion in the substantia nigra compared with wild-type mice
• decreased proteasome activity in the midbrain
• induced autophagy in the substantia nigra pars compacta
• impaired basal mitochondria respiration rate in the midbrain at 1 to 3 months

nervous system
• at 16 to 17 and 22 to 23 months
• however, not increase in apoptosis is observed
• through autophagy without an increase in reactive oxygen species production

behavior/neurological
• at 23 months

homeostasis/metabolism
• induced autophagy in the substantia nigra pars compacta

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:PS168600
J:188914


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory