Mouse Genome Informatics
tg
    Tg(Th-Peo1*,-EGFP)2Gcor/0
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cellular
• mice accumulate mitochondrial DNA deletion in the substantia nigra compared with wild-type mice
• decreased proteasome activity in the midbrain
• induced autophagy in the substantia nigra pars compacta
• impaired basal mitochondria respiration rate in the midbrain at 1 to 3 months

nervous system
• at 16 to 17 and 22 to 23 months
• through autophagy without an increase in reactive oxygen species production
• however, not increase in apoptosis is observed

behavior/neurological
• at 23 months

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease, Mitochondrial 556500 J:188914