Phenotypes for Ctnnb1 Tcf21 MGI:5446892 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tcf21^tm1(cre)Seq/Tcf21⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (47 available)
Tcf21^tm1(cre)Seq mutation (0 available); any Tcf21 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:189643 )

• embryos die between E12.5 and birth

renal/urinary system

abnormal kidney development ( J:189643 )

• about 33% of mutants have hypoplastic/dysplastic kidneys with a few disorganized glomeruli

renal hypoplasia ( J:189643 )

• most kidneys show some degree of hypoplasia

fused kidneys ( J:189643 )

• at E18.5 about 66.5% of mutants display kidney fusion at the midline

neoplasm

increased tumor incidence ( J:189643 )

• 100% of mutants display embryonic tumor affecting kidney, gut, heart, and lungs, which appears to arise from multiple mesenchymal tissues

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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