Phenotypes Associated with This Genotype

Genotype
MGI:5446814

• Allelic Composition: Plekha5^{Tg(AMH-cre)1Flor}/Plekha5^{Tg(AMH-cre)1Flor}
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal male germ cell apoptosis ( J:189585 )

abnormal Sertoli cell morphology ( J:189585 )

• Sertoli cells exhibit impaired peroxisome biogenesis and reactive oxygen species metabolism compared with wild-type cells

cellular

abnormal male germ cell apoptosis ( J:189585 )

abnormal peroxisome physiology ( J:189585 )

• Sertoli cells exhibit impaired peroxisome biogenesis and reactive oxygen species metabolism compared with wild-type cells

oxidative stress ( J:189585 )

• as indicated by impaired lipid peroxidation in Sertoli cells

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:189585 )

• Sertoli cells exhibit impaired peroxisome biogenesis and reactive oxygen species metabolism compared with wild-type cells