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Phenotypes Associated with This Genotype
Genotype
MGI:5446168
Allelic
Composition		 Klbtm1.2Sakl/Klbtm1.2Sakl
Genetic
Background		 involves: 129 * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klbtm1.2Sakl mutation (0 available); any Klb mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating triglyceride level ( J:189018 )
• in mice fed a high fat diet
abnormal glucose homeostasis ( J:189018 )
• mice injected with insulin and FGF21 fail to exhibit insulin sensitivity observed in FGF-treated control mice

growth/size/body
decreased body weight ( J:189018 )
• not as severe as in Klbtm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory