Analysis Tools
renal/urinary system
albuminuria
(
J:188500
)
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• as early as 4 weeks of age, mice exhibit significantly higher urinary albumin:creatinine ratios relative to wild-type controls
• at 2-6 months of age, albumin:creatinine ratios are significantly higher than those in podocyte-specific knockouts generated on a predominantly C57BL/6 background
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• by 4 months of age, the average number of foot processes per unit length of the basement membrane is reduced relative to than in wild-type controls
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• as early as 2 months of age, mice exhibit widespread foot process effacement, unlike wild-type controls
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• by 4 months of age, podocytes exhibit microvillus transformation, indicating damage
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• as early as 2 months of age, mice exhibit significant GBM alterations relative to wild-type controls
• by 4 months of age, a highly variable GBM disorganization with characteristic electronlucent or "moth-eaten" regions is observed, unlike in wild-type controls
• the overall GBM outline appears jagged and uneven
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• by 4 months of age, average GBM thickness is increased relative to that in wild-type controls
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• at 4 months of age, mice exhibit multiple sclerotic glomeruli, unlike control mice
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renal cast
(
J:188500
)
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• at 4 months of age, mice exhibit multiple renal casts, unlike control mice
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homeostasis/metabolism
albuminuria
(
J:188500
)
|
• as early as 4 weeks of age, mice exhibit significantly higher urinary albumin:creatinine ratios relative to wild-type controls
• at 2-6 months of age, albumin:creatinine ratios are significantly higher than those in podocyte-specific knockouts generated on a predominantly C57BL/6 background
|
