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Phenotypes Associated with This Genotype
Genotype
MGI:5445163
Allelic
Composition		 Flcntm1Baba/Flcntm1.1Lss
Tg(CAG-cre/Esr1*)1Lbe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flcntm1.1Lss mutation (0 available); any Flcn mutation (41 available)
Flcntm1Baba mutation (0 available); any Flcn mutation (41 available)
Tg(CAG-cre/Esr1*)1Lbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested B cell differentiation ( J:189078 )
• pro-B cell block in the bone marrow following tamoxifen-treatment
decreased B cell number ( J:189078 )
• CD19+ cells in the spleen following tamoxifen-treatment

renal/urinary system
kidney cyst ( J:189078 )
• in tamoxifen-treated mice
• in tamoxifen-treated mice however, kidney phenotype is rescued by rapamycin treatment
kidney failure ( J:189078 )
• in tamoxifen-treated mice
• however, kidney phenotype is rescued by rapamycin treatment

hematopoietic system
arrested B cell differentiation ( J:189078 )
• pro-B cell block in the bone marrow following tamoxifen-treatment
decreased B cell number ( J:189078 )
• CD19+ cells in the spleen following tamoxifen-treatment

growth/size/body
kidney cyst ( J:189078 )
• in tamoxifen-treated mice
• in tamoxifen-treated mice however, kidney phenotype is rescued by rapamycin treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory