Phenotypes Associated with This Genotype

Genotype
MGI:5445107

• Allelic Composition: St3gal6^tm1.1Jxm/St3gal6^tm1.1Jxm
• Genetic Background: B6.Cg-St3gal6^tm1.1Jxm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:189086 )

N • mice exhibit normal leukocytosis, thrombopoiesis and recruitment of monocytes

impaired leukocyte tethering or rolling ( J:189086 )

• modestly impaired P- and E-selectin-dependent rolling impaired rolling under dynamic flow conditions

• impaired P-selectin-dependent rolling during inflammation in vivo

• however, in vivo inflammation induced E-selectin-dependent rolling is normal

impaired neutrophil recruitment ( J:189086 )

• moderately impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate

cellular

impaired leukocyte tethering or rolling ( J:189086 )

• modestly impaired P- and E-selectin-dependent rolling impaired rolling under dynamic flow conditions

• impaired P-selectin-dependent rolling during inflammation in vivo

• however, in vivo inflammation induced E-selectin-dependent rolling is normal

hematopoietic system

impaired leukocyte tethering or rolling ( J:189086 )

• modestly impaired P- and E-selectin-dependent rolling impaired rolling under dynamic flow conditions

• impaired P-selectin-dependent rolling during inflammation in vivo

• however, in vivo inflammation induced E-selectin-dependent rolling is normal

impaired neutrophil recruitment ( J:189086 )

• moderately impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate