Phenotypes for Irx3 Irx5 Isl1 MGI:5444491 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Isl1^tm1(cre)Sev/Isl1⁺
Genetic Background	involves: 129S/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3^tm3Hui mutation (0 available); any Irx3 mutation (24 available)
Irx5^tm3Hui mutation (0 available); any Irx5 mutation (30 available)
Isl1^tm1(cre)Sev mutation (1 available); any Isl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:189007 )

• phenocopies abnormalities seen in germ line double null mice

persistent truncus arteriosus ( J:189007 )

double outlet right ventricle ( J:189007 )

abnormal interatrial septum morphology ( J:189007 )

• absence of the dorsal mesenchymal protrusion and the septum primum

atrial septal defect ( J:189007 )

• appears to be due to a defect in the fusion between the atrioventricular endocardial cushions and the dorsal mesenchymal protrusion

atrioventricular septal defect ( J:189007 )

• atrioventricular canal defect

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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