Phenotypes Associated with This Genotype

Genotype
MGI:5444197

• Allelic Composition: Pparg^tm2Rev/Pparg^tm2Rev; Tg(Tek-cre)12Flv/?
• Genetic Background: B6.Cg-Pparg^tm2Rev Tg(Tek-cre)12Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:154216 )

• about 5% less than controls

enlarged spleen ( J:154216 )

immune system

enlarged spleen ( J:154216 )

hematopoietic system

enlarged spleen ( J:154216 )

decreased hematocrit ( J:154216 )

• slightly reduced hematocrit

cardiovascular system

increased mean systemic arterial blood pressure ( J:154216 )

• higher baseline pressure

• greater increase when challenged with angiotensin II

abnormal vascular endothelial cell physiology ( J:154216 )

• reduced NO production in blood vessel endothelium

abnormal vasodilation ( J:154216 )

• impaired endothelium dependent acetylcholine mediated relaxation of aortic rings

muscle

abnormal vasodilation ( J:154216 )

• impaired endothelium dependent acetylcholine mediated relaxation of aortic rings

impaired muscle relaxation ( J:154216 )

• impaired endothelium dependent acetylcholine mediated relaxation of aortic rings