Phenotypes Associated with This Genotype

Genotype
MGI:5443929

• Allelic Composition: Cd109^tm1Mat/Cd109^tm1Mat
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

skin inflammation ( J:188696 )

• inflammatory cell infiltration in the dermis at P21

abnormal skin adnexa morphology ( J:188696 )

sebaceous gland hyperplasia ( J:188696 )

• apparent at P7 and sustained until P70

abnormal hair growth ( J:188696 )

• first detected at P7 and persists to P28

• hair growth is less directed

• hair growth recovers with age, with no severe impairment detected by P35

• at P14 some hairs fail to penetrate the epidermis

sparse hair ( J:188696 )

abnormal hair shaft morphology ( J:188696 )

• at P14, some hair shafts are kinky or zigzagged

abnormal hair follicle infundibulum morphology ( J:188696 )

• hyperplasia of the epidermis in the infundibular portions of the hair follicles

dilated hair follicle ( J:188696 )

• many follicles are ectatic at P21 with an accumulation of sebum

abnormal epidermal layer morphology ( J:188696 )

thick epidermis stratum basale ( J:188696 )

• apparent thickening

thick epidermis suprabasal layer ( J:188696 )

• apparent thickening

epidermal hyperplasia ( J:188696 )

• apparent at P7 and sustained until P70

thick epidermis ( J:188696 )

• significant at most time points (except P35 and P42) after P7

• thickening is seen both in skin regions with and without hair

immune system

skin inflammation ( J:188696 )

• inflammatory cell infiltration in the dermis at P21

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:188696 )

• apparent at P7 and sustained until P70