Phenotypes Associated with This Genotype

Genotype
MGI:5442780

• Allelic Composition: Myd88^tm1Hlz/Myd88^tm1Hlz; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: B6.129P2-Myd88^tm1Hlz Lyz2^tm1(cre)Ifo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating chemokine level ( J:188968 )

• in a CASP model of septic peritonitis, mice exhibit reduced circulating CXCL1 compared with control mice

increased circulating tumor necrosis factor level ( J:188968 )

• in a model of septic peritonitis

increased circulating alanine transaminase level ( J:188968 )

• in a model of septic peritonitis

increased circulating aspartate transaminase level ( J:188968 )

• in a model of septic peritonitis

decreased CXCL10 level ( J:188968 )

• in response to septic peritonitis, the peritoneal lavage fluid contains less CXCL10 compared with control mice

increased susceptibility to injury ( J:188968 )

• in a model of septic peritonitis, mice exhibit aggravated liver injury compared with control mice

immune system

immune system phenotype ( J:188968 )

N • mice exhibit normal expression of cytokines and neutrophil accumulation in inflammatory models

abnormal circulating chemokine level ( J:188968 )

• in a CASP model of septic peritonitis, mice exhibit reduced circulating CXCL1 compared with control mice

increased circulating tumor necrosis factor level ( J:188968 )

• in a model of septic peritonitis

decreased CXCL10 level ( J:188968 )

• in response to septic peritonitis, the peritoneal lavage fluid contains less CXCL10 compared with control mice