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Phenotypes Associated with This Genotype
Genotype
MGI:5442315
Allelic
Composition
Prkcshtm1Som/Prkcshtm1Som
Tg(CAG-cre/Esr1*)1Lbe/0
Genetic
Background
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcshtm1Som mutation (0 available); any Prkcsh mutation (23 available)
Tg(CAG-cre/Esr1*)1Lbe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in mice treated with a high does tamoxifen induction regime

liver/biliary system
• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic liver disease DOID:0050770 OMIM:174050
J:188763


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/05/2019
MGI 6.13
The Jackson Laboratory