Mouse Genome Informatics
tg
    Tg(OMP-SV40T)13Bse/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• starting from 4 months of age, mutants present with highly metastatic tumors originating in the adrenal medulla or sympathetic ganglia
• metastasis into liver, lungs, and para-aortic lymph nodes
• starting from 4 months of age, mutants present with highly metastatic tumors originating in the adrenal medulla or sympathetic ganglia that resemble human infant neuroblastoma
• tumor incidence is 18%
• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes
• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes

mortality/aging
• some mutants die from intra-abdominal bleeding from spontaneously ruptured, highly vascularized adrenal tumors

immune system
• 4-week old mutants do not have measurable levels of antibodies against SV40 Tag, but by 5 months of age, they show a humoral immune response against the transgene product, indicating a lack of immunological tolerance to Tag
• adrenal glands with no evidence of tumors show lymphocytic infiltrations, signs of medullary cell destruction and hemorrhagic areas at the cortico-medullary border

Mouse Models of Human Disease
OMIM IDRef(s)
Neuroblastoma, Susceptibility to 256700 J:54269