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Phenotypes Associated with This Genotype
Genotype
MGI:5442284
Allelic
Composition
Tg(OMP-SV40T)13Bse/0
Genetic
Background
involves: C57BL/6 * SJL
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes

nervous system
• starting from 4 months of age, mutants present with highly metastatic tumors originating in the adrenal medulla or sympathetic ganglia that resemble human infant neuroblastoma
• tumor incidence is 18%
• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes

neoplasm
• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes
• starting from 4 months of age, mutants present with highly metastatic tumors originating in the adrenal medulla or sympathetic ganglia
• metastasis into liver, lungs, and para-aortic lymph nodes
• starting from 4 months of age, mutants present with highly metastatic tumors originating in the adrenal medulla or sympathetic ganglia that resemble human infant neuroblastoma
• tumor incidence is 18%
• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes

mortality/aging
• some mutants die from intra-abdominal bleeding from spontaneously ruptured, highly vascularized adrenal tumors

immune system
• 4-week old mutants do not have measurable levels of antibodies against SV40 Tag, but by 5 months of age, they show a humoral immune response against the transgene product, indicating a lack of immunological tolerance to Tag
• adrenal glands with no evidence of tumors show lymphocytic infiltrations, signs of medullary cell destruction and hemorrhagic areas at the cortico-medullary border

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuroblastoma, Susceptibility to 256700 J:54269


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory