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Phenotypes Associated with This Genotype
Genotype
MGI:5441551
Allelic
Composition
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Lejo/Trp53tm1Lejo
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (4 available); any Rb1 mutation (61 available)
Trp53tm1Lejo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• adenovirus-FLPe/IRES/Cre (Ad-FIC) induces a dose dependent increase in mortality with no mice surviving to 55 weeks post infection at concentrations greater than or equal to 5.00E+06 infectious units (iu)
• no mice survive to 40 weeks post infection when dosed with 5.00E+07 iu of Ad-FIC

neoplasm
• following infection with Ad-FIC
• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection

respiratory system
• following infection with Ad-FIC
• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection
• neuroendocrine hyperplasia is detected at 8 weeks post infection with Ad-FIC

Mouse Models of Human Disease
OMIM ID Ref(s)
Small Cell Cancer of the Lung 182280 J:187012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory