Mouse Genome Informatics
cn
    Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Lejo/Trp53tm1Lejo

involves: 129
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• adenovirus-FLPe/IRES/Cre (Ad-FIC) induces a dose dependent increase in mortality with no mice surviving to 55 weeks post infection at concentrations greater than or equal to 5.00E+06 infectious units (iu)
• no mice survive to 40 weeks post infection when dosed with 5.00E+07 iu of Ad-FIC

tumorigenesis
• following infection with Ad-FIC
• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection

respiratory system
• neuroendocrine hyperplasia is detected at 8 weeks post infection with Ad-FIC

Mouse Models of Human Disease
OMIM IDRef(s)
Small Cell Cancer of the Lung 182280 J:187012