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Phenotypes Associated with This Genotype
Genotype
MGI:5441342
Allelic
Composition		 Hbb-b1tm1Unc/Hbb-b1+
Hbb-b2tm1Unc/Hbb-b2+
Tmprss6tm1Otin/Tmprss6+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1tm1Unc mutation (2 available); any Hbb-b1 mutation (8 available)
Hbb-b2tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)
Tmprss6tm1Otin mutation (0 available); any Tmprss6 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythrocyte cell number ( J:185154 )
• increased in males and females compared to mutant male and female mice wild-type for Tmprss6 at 6 months of age
abnormal hemoglobin content ( J:185154 )
• increased in males compared to mutant male mice wild-type for Tmprss6
decreased mean corpuscular volume ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6 at 6 months of age
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal spleen size ( J:185154 )
• reduced size in males compared to mutant male mice wild-type for Tmprss6

homeostasis/metabolism
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal circulating erythropoietin level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal liver iron level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6

liver/biliary system
abnormal liver iron level ( J:185154 )
• decreased in males compared to mutant male mice wild-type for Tmprss6

immune system
abnormal spleen iron level ( J:185154 )
• total spleen iron, but not iron per gram of tissue, is decreased in males compared to mutant male mice wild-type for Tmprss6
abnormal spleen size ( J:185154 )
• reduced size in males compared to mutant male mice wild-type for Tmprss6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory