Phenotypes Associated with This Genotype

Genotype
MGI:5440857

• Allelic Composition: a/a; Myo5a^d/Myo5a^d
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/hair pigmentation ( J:12958 )

diluted coat color ( J:12958 )

• clumping of melanin pigment into large granular clumps in medullary cells reduces the amount of light absorbed producing a blue-gray cast to the coat color

abnormal hair shaft morphology ( J:12958 )

• clumping of pigment creates local increase in hair diameter

• there are occasional large masses in air spaces between the medullary discs

abnormal hair shaft melanin granule distribution ( J:12958 )

• pigment clumps within medullary cells

• shape, size, color, amount and color of melanin are normal

pigmentation

abnormal coat/hair pigmentation ( J:12958 )

diluted coat color ( J:12958 )

• clumping of melanin pigment into large granular clumps in medullary cells reduces the amount of light absorbed producing a blue-gray cast to the coat color

abnormal eye pigmentation ( J:12958 )

• reduction in cortical pigment dulls the eye color compared with wild-type

abnormal melanocyte morphology ( J:12970 )

• fewer and thinner dendritic processes compared with wild-type mice

• melanin granules concentrated in the center of cells

abnormal hair shaft melanin granule distribution ( J:12958 )

• pigment clumps within medullary cells

• shape, size, color, amount and color of melanin are normal

vision/eye

abnormal eye pigmentation ( J:12958 )

• reduction in cortical pigment dulls the eye color compared with wild-type