Phenotypes Associated with This Genotype

Genotype
MGI:5440503

• Allelic Composition: Tenm4^{Tg(Col2a1-Hspg2)2Yoya}/Tenm4^{Tg(Col2a1-Hspg2)2Yoya}
• Genetic Background: C57BL/6-Tenm4^{Tg(Col2a1-Hspg2)2Yoya}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal oligodendrocyte apoptosis ( J:187705 )

• increased TUNNEL staining

abnormal oligodendrocyte morphology ( J:187705 )

• defective oligodendrocyte differentiation in vivo and in vitro

abnormal spinal cord white matter morphology ( J:187705 )

• reduced

• defect in myelin formation is more severe in the corticospinal tract of the dorsal funiculus and the fasciculus gracilis

abnormal spinal cord dorsal column morphology ( J:187705 )

• defect in myelin formation is more severe in the corticospinal tract of the dorsal funiculus

demyelination ( J:187705 )

• in the white matter of the spinal cord

• defect in myelin formation is more severe in the corticospinal tract of the dorsal funiculus and the fasciculus gracilis

• reduced myelination in axons of smaller diameter

• however, myelination of larger-diameter axons are normal

behavior/neurological

tremors ( J:187705 )

• severe in the hindlimbs 4 weeks after birth when walking

hindlimb paralysis ( J:187705 )

• on rare occasion

growth/size/body

decreased body size ( J:187705 )

decreased body weight ( J:187705 )

cellular

abnormal oligodendrocyte apoptosis ( J:187705 )

• increased TUNNEL staining