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Phenotypes Associated with This Genotype
Genotype
MGI:5440240
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (24 available)
Tsc2tm1.1Mjg mutation (1 available); any Tsc2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased male germ cell number ( J:187754 )
• mutants show complete or partial loss of germ cells
increased Sertoli cell proliferation ( J:187754 )
• adult Sertoli cells show disruption of cell cycle quiescence and thus increased proliferation in mice older than 4 months of age

reproductive system
decreased male germ cell number ( J:187754 )
• mutants show complete or partial loss of germ cells
abnormal testis morphology ( J:187754 )
• testicular junction integrity is compromised
increased Sertoli cell proliferation ( J:187754 )
• adult Sertoli cells show disruption of cell cycle quiescence and thus increased proliferation in mice older than 4 months of age
abnormal seminiferous tubule morphology ( J:187754 )
• mutants show complete or partial loss of germ cells and tubules with only Sertoli cells
abnormal seminiferous tubule epithelium morphology ( J:187754 )
• testes show vacuolization of seminiferous epithelium
abnormal Sertoli cell morphology ( J:187754 )
• Sertoli cells show disruption of the spoke-like pattern of microtubules and loss of apical extensions, and disruption of actin filament arrangement, indicating disruption of polarity
small testis ( J:187754 )
• in adults
abnormal spermatogenesis ( J:187754 )
• immature round germ cells are seen in the epididymides whereas only mature elongated germ cells are seen in controls

endocrine/exocrine glands
abnormal testis morphology ( J:187754 )
• testicular junction integrity is compromised
increased Sertoli cell proliferation ( J:187754 )
• adult Sertoli cells show disruption of cell cycle quiescence and thus increased proliferation in mice older than 4 months of age
abnormal seminiferous tubule morphology ( J:187754 )
• mutants show complete or partial loss of germ cells and tubules with only Sertoli cells
abnormal seminiferous tubule epithelium morphology ( J:187754 )
• testes show vacuolization of seminiferous epithelium
abnormal Sertoli cell morphology ( J:187754 )
• Sertoli cells show disruption of the spoke-like pattern of microtubules and loss of apical extensions, and disruption of actin filament arrangement, indicating disruption of polarity
small testis ( J:187754 )
• in adults

neoplasm
neoplasm ( J:187754 )
N
• testicular tumors are not observed up to 10 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory