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Phenotypes Associated with This Genotype
Genotype
MGI:5440177
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (47 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (47 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Gt(ROSA)26Sortm1.1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal germ layer development ( J:187739 )
• at E8.5 embryos have a sac-like structure composed of 2 layers where the outer layer is reminiscent of the visceral endoderm and the inner layer has characteristics of a pseudostratified epithelium
failure to gastrulate ( J:187739 )
• expression analysis indicates failure to gastrulate
abnormal embryonic tissue morphology ( J:187739 )
• formation of proper embryonic structures is incomplete

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory