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Phenotypes Associated with This Genotype
Genotype
MGI:5440071
Allelic
Composition		 Braftm2Cpri/Braf+
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm2Cpri mutation (0 available); any Braf mutation (58 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast proliferation ( J:187371 )
• in primary mouse embryonic fibroblasts treated with adenovirus-cre compared with wild-type cells although not as much as in cells heterozygous for Krastm4Tyj

neoplasm
increased lung adenoma incidence ( J:187371 )
• in mice infected with adenovirus cre
• however, mice do not exhibit increased lung tumor incidence compared with Krastm4Tyj heterozygotes

respiratory system
increased lung adenoma incidence ( J:187371 )
• in mice infected with adenovirus cre
• however, mice do not exhibit increased lung tumor incidence compared with Krastm4Tyj heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory