Phenotypes Associated with This Genotype

Genotype
MGI:5439847

• Allelic Composition: Mcm9^tm1.1Geno/Mcm9^tm1.1Geno
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:187623 )

♂N • male mice are fertile

oligozoospermia ( J:187623 )

♂ • despite normal fertility

abnormal male germ cell apoptosis ( J:187623 )

♂ • slight

abnormal seminiferous tubule morphology ( J:187623 )

♂ • however, differentiation is normal

female infertility ( J:187623 )

♀

cellular

oligozoospermia ( J:187623 )

♂ • despite normal fertility

abnormal cell nucleus morphology ( J:187623 )

• micronuclei in mouse embryonic fibroblasts

polyploidy ( J:187623 )

• 4n in some mouse embryonic fibroblasts

increased cellular sensitivity to gamma-irradiation ( J:187623 )

abnormal male germ cell apoptosis ( J:187623 )

♂ • slight

decreased fibroblast proliferation ( J:187623 )

• of mouse embryonic fibroblasts

abnormal DNA replication ( J:187623 )

• mouse embryonic fibroblasts exhibit hypersensitivity to replication fork stress

spontaneous chromosome breakage ( J:187623 )

• broken or aberrant chromosomes in mouse embryonic fibroblasts

homeostasis/metabolism

abnormal DNA replication ( J:187623 )

• mouse embryonic fibroblasts exhibit hypersensitivity to replication fork stress

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:187623 )

♂ • however, differentiation is normal