Phenotypes Associated with This Genotype

Genotype
MGI:5439367

• Allelic Composition: Rnf43^tm1Cle/Rnf43^tm1Cle; Znrf3^tm1Cle/Znrf3^tm1Cle; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal small intestinal crypt cell proliferation ( J:186765 )

• following tamoxifen treatment a marked expansion of the proliferative compartment is seen

abnormal small intestine crypts of Lieberkuhn morphology ( J:186765 )

• following tamoxifen treatment a marked expansion of the proliferative compartment is seen with enlarged crypts and Ki67+ cells ectopically located on the flanks of villi

• increase in the number of Olfm4+ stem cells after tamoxifen treatment

increased Paneth cell number ( J:186765 )

• increased number after tamoxifen treatment

increased intestinal adenoma incidence ( J:186765 )

• form within 1 month of clonal deletion induced by low dose tamoxifen treatment

• contain Olfm4+ stem cells and Paneth cells

neoplasm

increased intestinal adenoma incidence ( J:186765 )

• form within 1 month of clonal deletion induced by low dose tamoxifen treatment

• contain Olfm4+ stem cells and Paneth cells

cellular

abnormal small intestinal crypt cell proliferation ( J:186765 )

• following tamoxifen treatment a marked expansion of the proliferative compartment is seen

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:186765 )

• following tamoxifen treatment a marked expansion of the proliferative compartment is seen with enlarged crypts and Ki67+ cells ectopically located on the flanks of villi

• increase in the number of Olfm4+ stem cells after tamoxifen treatment

increased Paneth cell number ( J:186765 )

• increased number after tamoxifen treatment