Mouse Genome Informatics
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    Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
C.129-Traf3ip2tm1.1Lix
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mutants begin to die around 4 months of age and by 12 months of age, about 83% mutants are dead

immune system
• lymph nodes proximal to the submaxillary glands are greatly enlarged
• mutants, but not wild-type mice, develop anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens
• lymphocyte infiltration in lacrimal, parotid and submaxillary glands; most infiltrates are in the perivascular or periductal areas of the glands
• lymphocyte infiltration in submandibular glands
• lymphocyte infiltration in lacrimal glands
• lacrimal glands are infiltrated by B220+ B cells and T cells
• some mutants develop skin lesions around the eyes due to excessive scratching of affected eyes
• both males and females exhibit difficulties in maintaining fully opened eyelids beginning around 3 weeks of age due to inflammation
• mutants at 8-12 months of age exhibit lymphocyte infiltration in the kidney, including the glomeruli
• presence of anti-DNA autoantibodies and IgG complex in glomeruli, indicating development of glomerulonephritis

digestive/alimentary system
• mutants exhibit reduced flow rate of saliva production
• lymphocyte infiltration in parotid glands
• enlarged submaxillary glands
• lymphocyte infiltration in submandibular glands

renal/urinary system
• mutants at 8-12 months of age exhibit lymphocyte infiltration in the kidney, including the glomeruli
• presence of anti-DNA autoantibodies and IgG complex in glomeruli, indicating development of glomerulonephritis

craniofacial
• mouth inflammation
• mutants exhibit reduced flow rate of saliva production

endocrine/exocrine glands
• mutants exhibit reduced flow rate of saliva production
• lymphocyte infiltration in submandibular glands
• exocrine glands are infiltrated by large number of B and T cells
• lymphocyte infiltration in parotid glands
• enlarged submaxillary glands
• lymphocyte infiltration in lacrimal glands
• lacrimal glands are infiltrated by B220+ B cells and T cells

hematopoietic system

vision/eye
• lymphocyte infiltration in lacrimal glands
• lacrimal glands are infiltrated by B220+ B cells and T cells
• some mutants develop skin lesions around the eyes due to excessive scratching of affected eyes
• both males and females exhibit difficulties in maintaining fully opened eyelids beginning around 3 weeks of age due to inflammation

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:138560