Phenotypes Associated with This Genotype

Genotype
MGI:5438970

• Allelic Composition: Sh2d1a^tm1Pls/Sh2d1a^tm1Pls; Tg(TcraTcrb)1100Mjb/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytotoxic T cell physiology ( J:187431 )

• impaired adhesion to wild-type B cells when stimulated with ovalbumin

• however, T cells exhibit increased adhesion to and normal killing of B cells lacking Slamf6 (Sh2d1a^tm1Pls)

decreased cytotoxic T cell cytolysis ( J:187431 )

decreased interferon-gamma secretion ( J:187431 )

• in cytotoxic T cells stimulated with ovalbumin

hematopoietic system

abnormal cytotoxic T cell physiology ( J:187431 )

• impaired adhesion to wild-type B cells when stimulated with ovalbumin

• however, T cells exhibit increased adhesion to and normal killing of B cells lacking Slamf6 (Sh2d1a^tm1Pls)

decreased cytotoxic T cell cytolysis ( J:187431 )