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Phenotypes Associated with This Genotype
Genotype
MGI:5438795
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf14Tg(tetO-MAPT*P301L)4510Kha mutation (2 available); any Fgf14 mutation (40 available)
Tg(Camk2a-tTA)1Mmay mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dentate gyrus morphology ( J:185792 )
• progressive atrophy of dentate granule cells
hippocampal neuron degeneration ( J:185792 )
• progressive atrophy of hippocampal pyramidal neurons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory