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Phenotypes Associated with This Genotype
Genotype
MGI:5438775
Allelic
Composition		 Fgf10tm1.1(cre/ERT2)Sbel/Fgf10tm1Sms
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1.1(cre/ERT2)Sbel mutation (1 available); any Fgf10 mutation (31 available)
Fgf10tm1Sms mutation (0 available); any Fgf10 mutation (31 available)
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze mutation (7 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung bud morphology ( J:187831 )
• with tamoxifen administration to dams from E8.5 to 14.5, embryonic lungs display abnormal shape and simplified branching (reduced number of terminal buds in accessory lobe as example)

limbs/digits/tail
interdigital webbing ( J:187831 )
• with tamoxifen administration to dams from E8.5 to 14.5, webbed digits are observed at level of forelimbs in embryos

digestive/alimentary system
abnormal cecum development ( J:187831 )
• with tamoxifen administration to dams from E8.5 to 14.5, cecum length is decreased in embryos relative to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory