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Phenotypes Associated with This Genotype
Genotype
MGI:5438302
Allelic
Composition
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• spermatocytes exhibit homolog association and pairing at all tested chromosomal regions, although less than in wild-type spermatocytes
• spermocytes exhibit neither early centromere-associations nor preferential initiation of synaptonemal complex formation from centromeres (J:187173)
• spermatocytes form cohesion axes and axial elements but fail to undergo proper synapsis, arresting at the late leptotene or zygotene-like stage (J:209347)
• spermatocytes exhibit homolog association and pairing at all tested chromosomal regions, although less than in wild-type spermatocytes (J:209347)
• spermatocytes arrest at the late leptotene or zygotene-like stage

cellular
• double-strand break formation is abolished

homeostasis/metabolism
• double-strand break formation is abolished


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory