Phenotypes Associated with This Genotype

Genotype
MGI:5438250

• Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis
• Genetic Background: B6.129P2-Lgr4^tm1.2Knis

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:172277 )

• at E18.5, half of the few remaining homozygotes (2 of 4) are already dead

• no homozygotes are obtained at E19.5

lethality throughout fetal growth and development, incomplete penetrance ( J:172277 )

• most homozygotes appear to die between E15.5 and E18.5

renal/urinary system

increased kidney apoptosis ( J:186318 )

• at E16.5, apoptosis is significantly induced in the renal peripheral zone, unlike in wild-type kidneys

• however, no significant difference in apoptosis is detected in the ureteric bud

kidney cyst ( J:172277 )

• by E16.5, all metanephric kidneys exhibit cystic changes, as indicated by dilated tubule formation

abnormal metanephric mesenchyme morphology ( J:186318 )

• at E16.5, disruption of the cap mesenchyme is observed

• PAX2-expressing cap mesenchyme is longer detectable at E16.5

abnormal metanephric ureteric bud development ( J:172277 )

• at E15.5, the ureteric bud undergoes premature epithelial differentiation

small metanephros ( J:172277 )

• smaller sized kidneys at E16.5

renal hypoplasia ( J:172277 )

• severe renal hypoplasia by E16.5

impaired branching involved in ureteric bud morphogenesis ( J:172277 )

• at E15.5, impaired ureteric branching morphogenesis is observed, unlike in wild-type control kidneys

cellular

increased kidney apoptosis ( J:186318 )

• at E16.5, apoptosis is significantly induced in the renal peripheral zone, unlike in wild-type kidneys

• however, no significant difference in apoptosis is detected in the ureteric bud

growth/size/body

kidney cyst ( J:172277 )

• by E16.5, all metanephric kidneys exhibit cystic changes, as indicated by dilated tubule formation