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Phenotypes Associated with This Genotype
Genotype
MGI:5438241
Allelic
Composition
Cul4btm1Swl/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
B6.Cg-Edil3Tg(Sox2-cre)1Amc Cul4btm1Swl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4btm1Swl mutation (0 available); any Cul4b mutation (29 available)
Edil3Tg(Sox2-cre)1Amc mutation (4 available); any Edil3 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• hippocampal neurons exhibit reduced dendritic complexity and spine density compared with control neurons
• hippocampal neurons exhibit reduced dendritic complexity and spine density compared with control neurons
• fewer PV+ hippocampal neurons
• however, mice exhibit normal numbers of SS+ and GAD67+ neurons

behavior/neurological
• impaired in a Morris water maze
• impaired in a Morris water maze

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
intellectual disability DOID:1059 J:187403


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory