Phenotypes Associated with This Genotype

Genotype
MGI:5438105

• Allelic Composition: Cox4i2^tm1Hutt/Cox4i2^tm1Hutt
• Genetic Background: B6.129-Cox4i2^tm1Hutt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung morphology ( J:187640 )

• nearly all mice with lung inflammation also have Charcot-Leyden crystals, hexagonal colorless crystals, within the granulomas or the bronchi

• at 40 weeks of age crystals are seen in the lungs of all females and similar changes are seen in males

pulmonary fibrosis ( J:187640 )

• at 40 weeks of age in some mice with lung inflammation

abnormal respiratory system physiology ( J:187640 )

• decrease in cytochrome c oxidase (COX) activity and ATP levels in the lungs

lung inflammation ( J:187640 )

• at 18 weeks of age in approximately half of the mice

• variable increase in the number of inflammatory cells recovered from the lungs at 33 weeks of age

• at 40 weeks of age all females show mild to moderate chronic inflammation and similar changes are seen in males

decreased airway responsiveness ( J:187640 )

• decrease in methacholine induced enhanced pauses in breathing at low doses of methacholine

• decrease in airway reactivity to methacholine

growth/size/body

decreased lean body mass ( J:187640 )

• decreased 12% in females but only about 2% in males

homeostasis/metabolism

improved glucose tolerance ( J:187640 )

♀ • females but not males have lower glucose levels in a glucose tolerance test compared to controls

behavior/neurological

decreased grip strength ( J:187640 )

♀ • significant decrease in females (~14%) but not in males (6%)

immune system

immune system phenotype ( J:233986 )

N • following ovalbumin (OVA) sensitization and repeated OVA airway challenge, mice show no alterations in the humoral or cellular immune response compared to challenged wild-type mice

lung inflammation ( J:187640 )

• at 18 weeks of age in approximately half of the mice

• variable increase in the number of inflammatory cells recovered from the lungs at 33 weeks of age

• at 40 weeks of age all females show mild to moderate chronic inflammation and similar changes are seen in males