Phenotypes Associated with This Genotype

Genotype
MGI:5437997

• Allelic Composition: rda/rda
• Genetic Background: C57BL/6J-rda/JKjn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cochlear hair cell abnormalities in rda/rda and Elmod1^rda-2J/Elmod1^rda-2J mice

hearing/vestibular/ear

abnormal inner hair cell stereociliary bundle morphology ( J:187273 )

• lengthened and fused at P15

fused inner hair cell stereocilia ( J:187273 )

• at P15

abnormal outer hair cell stereociliary bundle morphology ( J:187273 )

• in a few outer hair cells at P7 and P10

absent outer hair cell stereocilia ( J:187273 )

• in some cells at P15

decreased outer hair cell stereocilia number ( J:187273 )

• in a few outer hair cells at P7 and P10 adjacent to the kinocilium

• degeneration in all outer hair cells at P15

organ of Corti degeneration ( J:187273 )

• at 4 months

increased or absent threshold for auditory brainstem response ( J:187273 )

deafness ( J:187273 )

• profound by 5 weeks

behavior/neurological

absent startle reflex ( J:187273 )

circling ( J:187273 )

nervous system

abnormal inner hair cell stereociliary bundle morphology ( J:187273 )

• lengthened and fused at P15

fused inner hair cell stereocilia ( J:187273 )

• at P15

abnormal outer hair cell stereociliary bundle morphology ( J:187273 )

• in a few outer hair cells at P7 and P10

absent outer hair cell stereocilia ( J:187273 )

• in some cells at P15

decreased outer hair cell stereocilia number ( J:187273 )

• in a few outer hair cells at P7 and P10 adjacent to the kinocilium

• degeneration in all outer hair cells at P15

cochlear ganglion degeneration ( J:187273 )

• at 4 months