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Spontaneous Allele Detail
Symbol: rda
Name: roundabout
MGI ID: MGI:3055794
Synonyms: vertigo, vto
Gene: rda  Location: unknown  Genetic Position: Chr9, Syntenic
Alliance: rda page
Cochlear hair cell abnormalities in rda/rda and Elmod1rda-2J/Elmod1rda-2J mice

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Intergenic deletion
  rda involves 2 genes/genome features (Elmod1, Tnfaip8l3) View all
Mutation detailsA spontaneous deletion removed 138 kb, including exons 1-5 of Elmod1 and Tnfaip8l3. Western blot analysis confirmed the absence of protein expression in the brain. (J:187273)
Inheritance:    Recessive
Molecular structure of the rda mutation
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any rda Mutation:  1 strain or line available
Original:  J:187273 Johnson KR, et al., Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia. PLoS One. 2012;7(4):e36074
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory