Analysis Tools
renal/urinary system
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• mice exhibit normal kidney size, renal histology, and renal function throughout a 6-month observation period
• at 8-10 weeks of age, BUN levels and serum creatinine levels are normal relative to those in wild-type controls
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• following bilateral kidney ischemia/reperfusion injury, mice exhibit decreased creatinine plasma levels, significantly less cortical and outer medulla tubular damage, lower tubular apoptosis, and improved survival relative to wild-type controls
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homeostasis/metabolism
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• following bilateral kidney ischemia/reperfusion injury, mice exhibit decreased creatinine plasma levels, significantly less cortical and outer medulla tubular damage, lower tubular apoptosis, and improved survival relative to wild-type controls
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