Phenotypes Associated with This Genotype

Genotype
MGI:5437713

• Allelic Composition: Fas^lpr/Fas^lpr; Havcr1^tm1Kuch/Havcr1^tm1Kuch
• Genetic Background: B6.Cg-Havcr1^tm1Kuch Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:186484 )

• more severe in mice over 10 months of age compared to mice homozygous for Fas^lpr alone

increased B cell number ( J:186484 )

• massive accumulation of B cells

increased T cell number ( J:186484 )

• increase in the number of B220+CD3+ T cells in the peripheral lymphoid compartments compared to mice homozygous for Fas^lpr alone

increased double-negative T cell number ( J:186484 )

• massive increase in CD3+B220-CD4-CD8- and CD3+B220+CD4-CD8- T cells

increased CD4-positive, alpha-beta T cell number ( J:186484 )

• massive increase in the accumulation of CD3+B220- CD4+ T cells

• increase in the frequency of IFNG+ cells

increased CD8-positive, alpha-beta T cell number ( J:186484 )

• massive increase in the accumulation of CD3+B220- CD8+ T cells

• increase in the frequency of IFNG+ cells

increased activated T cell number ( J:186484 )

• most T cells have an activated/memory like phenotype

abnormal immunoglobulin level ( J:186484 )

• unlike IgG levels, IgM levels are decreased compared to mice homozygous for Fas^lpr alone

increased IgG1 level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

increased IgG2a level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

increased IgG2b level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

increased IgG3 level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

enlarged lymph nodes ( J:186484 )

• more severe in mice over 10 months of age compared to mice homozygous for Fas^lpr alone

increased susceptibility to systemic lupus erythematosus ( J:186484 )

• more severe autoimmune response compared to mice homozygous for Fas^lpr alone

increased autoantibody level ( J:186484 )

• serum levels of some autoantibodies to lupus associated autoantigens are increased at 14 weeks of age in double mutant mice but not in mice homozygous for Fas^lpr alone

• autoantibodies can be detected as early as 10 weeks of age

increased anti-double stranded DNA antibody level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

hematopoietic system

enlarged spleen ( J:186484 )

• more severe in mice over 10 months of age compared to mice homozygous for Fas^lpr alone

increased B cell number ( J:186484 )

• massive accumulation of B cells

increased T cell number ( J:186484 )

• increase in the number of B220+CD3+ T cells in the peripheral lymphoid compartments compared to mice homozygous for Fas^lpr alone

increased double-negative T cell number ( J:186484 )

• massive increase in CD3+B220-CD4-CD8- and CD3+B220+CD4-CD8- T cells

increased CD4-positive, alpha-beta T cell number ( J:186484 )

• massive increase in the accumulation of CD3+B220- CD4+ T cells

• increase in the frequency of IFNG+ cells

increased CD8-positive, alpha-beta T cell number ( J:186484 )

• massive increase in the accumulation of CD3+B220- CD8+ T cells

• increase in the frequency of IFNG+ cells

increased activated T cell number ( J:186484 )

• most T cells have an activated/memory like phenotype

abnormal immunoglobulin level ( J:186484 )

• unlike IgG levels, IgM levels are decreased compared to mice homozygous for Fas^lpr alone

increased IgG1 level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

increased IgG2a level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

increased IgG2b level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

increased IgG3 level ( J:186484 )

• compared to mice homozygous for Fas^lpr alone

growth/size/body

enlarged spleen ( J:186484 )

• more severe in mice over 10 months of age compared to mice homozygous for Fas^lpr alone