Phenotypes Associated with This Genotype

Genotype
MGI:5435703

• Allelic Composition: Shank2^tm1.1Tmb/Shank2⁺
• Genetic Background: B6.129-Shank2^tm1.1Tmb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:186719 )

behavior/neurological

increased anxiety-related response ( J:186719 )

increased locomotor activity ( J:186719 )

• in an open field assay

nervous system

abnormal excitatory postsynaptic potential ( J:186719 )

• field excitatory postsynaptic potentials are decreased by about 40% in CA1 pyramidal cells in acute hippocampal slices from mice at age P21-P28