Phenotypes Associated with This Genotype

Genotype
MGI:5435264

• Allelic Composition: Syf2^{Gt(PST25562)Mfgc}/Syf2^{Gt(PST25562)Mfgc}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Aberrant development in Syf2^{Gt(PST25562)Mfgc}/Syf2^{Gt(PST25562)Mfgc} embryos

mortality/aging

embryonic lethality, complete penetrance ( J:187030 )

• die before E11.5

embryo

failure to gastrulate ( J:187030 )

• do not undergo normal gastrulation

failure of blastocyst to hatch from the zona pellucida ( J:187030 )

abnormal embryonic tissue morphology ( J:187030 )

• at E8.5. and E9.5 display severely impaired development of head, trunk, and appendages

cellular

abnormal cell cycle checkpoint function ( J:187030 )

• insufficient checkpoint capacity at G2/M to arrest cell cycle progression