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Phenotypes Associated with This Genotype
Genotype
MGI:5433579
Allelic
Composition		 Bcl2l11tm1.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (33 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• median survival is 64 days; survival is decreased compared to single Tg(IghMyc)22Bri hemizygotes which live to about 100 days

neoplasm
increased T cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a rare incidence of Thy1+ T lymphoma
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mixture of sIg- pre-B lymphoma (~65%) and sIg+ B lymphoma (~35%)

hematopoietic system
increased leukocyte cell number ( J:186117 )
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

immune system
increased leukocyte cell number ( J:186117 )
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a rare incidence of Thy1+ T lymphoma

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory