Phenotypes Associated with This Genotype

Genotype
MGI:5432888

• Allelic Composition: Rasgrp4^{tm1a(KOMP)Lste}/Rasgrp4^{tm1a(KOMP)Lste}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal neutrophil physiology ( J:186412 )

• across all times of stimulation and doses of agonist, neutrophils exhibit reduced reactive oxygen species production compared with wild-type cells

• PMA-stimulated neutrophils exhibit increased reactive oxygen species production compared with wild-type cells

impaired neutrophil chemotaxis ( J:186412 )

• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells

• however, migration into an aseptically inflamed peritoneum is normal

cellular

impaired neutrophil chemotaxis ( J:186412 )

• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells

• however, migration into an aseptically inflamed peritoneum is normal

hematopoietic system

abnormal neutrophil physiology ( J:186412 )

• across all times of stimulation and doses of agonist, neutrophils exhibit reduced reactive oxygen species production compared with wild-type cells

• PMA-stimulated neutrophils exhibit increased reactive oxygen species production compared with wild-type cells

impaired neutrophil chemotaxis ( J:186412 )

• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells

• however, migration into an aseptically inflamed peritoneum is normal