Rasgrp4^{tm1a(KOMP)Lste}
Targeted Allele Detail

Summary

• Symbol: Rasgrp4^{tm1a(KOMP)Lste}
• Name: RAS guanyl releasing protein 4; targeted mutation 1a, Len Stephens
• MGI ID: MGI:5432887
• Synonyms: RasGRP4^kof
• Gene: Rasgrp4 Location: Chr7:28834358-28853386 bp, + strand Genetic Position: Chr7, 16.94 cM, cytoband B1
• Alliance: Rasgrp4^{tm1a(KOMP)Lste} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186412
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The recombinase site flanked reporter cassette (FRT site, engrail2 splice acceptor, IRES, LacZ, polyadenylation sequence and loxP site) and selection cassettes (beta-geo, polyadenylation site, FRT site and loxP site) were inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 6. (J:186412)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasgrp4 Mutation: 41 strains or lines available

References

• Original: J:186412 Suire S, et al., GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. EMBO J. 2012 Jul 18;31(14):3118-29
• All: 1 reference(s)