About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5432240
Allelic
Composition
Apctm2Rak/Apctm2Rak
Krastm4Tyj/Kras+
Genetic
Background
involves: 129 * 129S4/SvJae * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rak mutation (1 available); any Apc mutation (59 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• 64% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are adenomas

neoplasm
• 36% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are carcinomas
• 20% of mutants injected with an adenovirus expressing cre recombinase in the distal colon to inactivate Apc exhibit spontaneous gross liver metastases starting 24 weeks after adenoviral injection; these lesions are adenocarcinomas
• 96% of mutants injected with an adenovirus expressing cre recombinase in the distal colon to inactivate Apc develop distal colonic tumors as little as 3 weeks after viral administration
• rapamycin treatment of mutants with tumors does not result in tumor regression
• 64% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are adenomas


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory