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Phenotypes Associated with This Genotype
Genotype
MGI:5432215
Allelic
Composition
Il10tm1Cgn/Il10tm1Cgn
Tg(MUC1)79.24Gend/0
Genetic
Background
B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (14 available); any Il10 mutation (31 available)
Tg(MUC1)79.24Gend mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• rectal prolapse is seen at a median time of 11 weeks of age
• 88% of mutants with colonic inflammation exhibit colon tumors; majority of tumors are invasive adenocarcinomas
• mutants exhibit a higher tumor burden (3-4 tumors per colon on average) than single Il10 homozygotes (1 tumor per colon)
• tumors develop as early as 8-12 weeks of age
• mutants develop segmental, patchy colon inflammation with areas of healthy-appearing colon adjacent to areas of severe inflammation
• mutants exhibit higher total colonic inflammation at 5-6 weeks of age than single Il10 homozygotes and show fewer fields of no inflammation
• neutrophils are the dominant cellular infiltrate in the colon which are not seen in the single Il10 homozygote
• mutants develop progressive inflammatory bowel disease much earlier than single Il10 homozygotes

immune system
• mutants develop segmental, patchy colon inflammation with areas of healthy-appearing colon adjacent to areas of severe inflammation
• mutants exhibit higher total colonic inflammation at 5-6 weeks of age than single Il10 homozygotes and show fewer fields of no inflammation
• neutrophils are the dominant cellular infiltrate in the colon which are not seen in the single Il10 homozygote
• mutants develop progressive inflammatory bowel disease much earlier than single Il10 homozygotes

neoplasm
• 88% of mutants with colonic inflammation exhibit colon tumors; majority of tumors are invasive adenocarcinomas
• mutants exhibit a higher tumor burden (3-4 tumors per colon on average) than single Il10 homozygotes (1 tumor per colon)
• tumors develop as early as 8-12 weeks of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory