Phenotypes Associated with This Genotype

Genotype
MGI:5432002

• Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S4/SvJae * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:186085 )

abnormal blood cell morphology/development ( J:186085 )

• 3-fold increase in the frequency of KLS cells (hematopoietic stem cells and multipotential progenitors)

extramedullary hematopoiesis ( J:186085 )

decreased bone marrow cell number ( J:186085 )

increased erythroid progenitor cell number ( J:186085 )

• 1.4-fold in the bone marrow

• 4-fold in the spleen

• increased mature erythroid (CFU-E) compared with immature erythroid (BFU-E)

increased erythrocyte cell number ( J:186085 )

polycythemia ( J:186085 )

• severe by 2 months

increased hematocrit ( J:186085 )

decreased lymphocyte cell number ( J:186085 )

increased hematopoietic stem cell number ( J:186085 )

skeleton

increased trabecular bone volume ( J:186085 )

• 2.5-fold in the metaphyseal region

increased osteoblast cell number ( J:186085 )

• increased trabecular osteoblasts

increased bone trabecula number ( J:186085 )

increased trabecular bone mass ( J:186085 )

• in the metaphyseal and diaphyseal regions

cardiovascular system

abnormal angiogenesis ( J:186085 )

• hypervasculatization of the bone

growth/size/body

decreased body size ( J:186085 )

enlarged spleen ( J:186085 )

homeostasis/metabolism

increased circulating erythropoietin level ( J:186085 )

immune system

enlarged spleen ( J:186085 )

decreased lymphocyte cell number ( J:186085 )

limbs/digits/tail

abnormal foot pad morphology ( J:186085 )

• red paw