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Phenotypes Associated with This Genotype
Genotype
MGI:5431980
Allelic
Composition		 Vps18tm1.1Wtao/Vps18tm1.1Wtao
Tg(Pcp2-cre)2Mpin/0
Genetic
Background		 B.129-Vps18tm1.1Wtao Tg(Pcp2-cre)2Mpin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pcp2-cre)2Mpin mutation (1 available)
Vps18tm1.1Wtao mutation (0 available); any Vps18 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Neurodegeneration in Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Nes-cre)1Kln/0 and Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Pcp2-cre)2Mpin/0 brains

nervous system
nervous system phenotype ( J:186307 )
N
• Purkinje cells proliferation is normal
decreased Purkinje cell number ( J:186307 )
• dramatic loss at 1 month
• very few Purkinje cells are present at 3 months

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory