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Phenotypes Associated with This Genotype
Genotype
MGI:5431238
Allelic
Composition
Tg(Thy1-Sncg)HvP36Putt/?
Genetic
Background
C57BL/6-Tg(Thy1-Sncg)HvP36Putt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-Sncg)HvP36Putt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• retinal ganglion cells do not exhibit deterioration or loss despite overexpression of gamma-synuclein (J:185793)
• retinal ganglion cells do not exhibit deterioration or loss despite overexpression of gamma-synuclein (J:185793)
• gliosis is observed within motor regions of cortex (J:185793)
• gliosis is observed within motor regions of cortex (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• loss of motor neurons is observed in the trigeminal motor nucleus, but not in the facial and abducens motor nuclei (J:185793)
• neuron loss is observed in select upper and lower motor neuron populations of the motor cortex, and to a lesser degree in the somatosensory regions (J:185793)
• neuron loss is correlated with perikaryal and axonal accumulation of gamma-synuclein, accumulation of detergent-insoluble species and gliosis (J:185793)
• loss of motor neurons is observed in the trigeminal motor nucleus, but not in the facial and abducens motor nuclei (J:185793)
• neuron loss is observed in select upper and lower motor neuron populations of the motor cortex, and to a lesser degree in the somatosensory regions (J:185793)
• neuron loss is correlated with perikaryal and axonal accumulation of gamma-synuclein, accumulation of detergent-insoluble species and gliosis (J:185793)
• damage to myelin sheath is observed in substantial numbers of myelinated fibers from the sciatic nerve in severely affected mice (J:185793)
• damage to myelin sheath is observed in substantial numbers of myelinated fibers from the sciatic nerve in severely affected mice (J:185793)
• selective neuronal dystrophy is observed in the cortex (J:185793)
• selective neuronal dystrophy is observed in the cortex (J:185793)
• significant neuron loss is observed in affected 12 month old mice (J:185793)
• mice exhibit high levels of astrogliosis and microgliosis in the trigeminal motor nucleus (J:185793)
• significant neuron loss is observed in affected 12 month old mice (J:185793)
• mice exhibit high levels of astrogliosis and microgliosis in the trigeminal motor nucleus (J:185793)
• some abnormal myelinated fibers and phagocytes are observed in the dorsal spinal root (J:185793)
• however, the majority of myelinated fibers are similar to control in number and condition (J:185793)
• some abnormal myelinated fibers and phagocytes are observed in the dorsal spinal root (J:185793)
• however, the majority of myelinated fibers are similar to control in number and condition (J:185793)
• deterioration and loss of myelinated axons in severely affected mice (J:185793)
• reduction in total numbers of myelinated fibers in severely affected mice (J:185793)
• reduced levels of neurofilament proteins, alpha tubulin, and myelin basic protein are observed in severely affected mice (J:185793)
• active Wallerian-like degeneration of the sciatic nerve is observed (J:185793)
• mildly affected mice exhibit slight changes in morphology, but no loss of fibers (J:185793)
• deterioration and loss of myelinated axons in severely affected mice (J:185793)
• reduction in total numbers of myelinated fibers in severely affected mice (J:185793)
• reduced levels of neurofilament proteins, alpha tubulin, and myelin basic protein are observed in severely affected mice (J:185793)
• active Wallerian-like degeneration of the sciatic nerve is observed (J:185793)
• mildly affected mice exhibit slight changes in morphology, but no loss of fibers (J:185793)
• deterioration and loss of myelinated fibers in severely affected mice (J:185793)
• significant decrease in mean myelinated fiber size (49.5%) found in remaining myelinated fibers (J:185793)
• extensive phagocyte infiltration (J:185793)
• deterioration and loss of myelinated fibers in severely affected mice (J:185793)
• significant decrease in mean myelinated fiber size (49.5%) found in remaining myelinated fibers (J:185793)
• extensive phagocyte infiltration (J:185793)

hematopoietic system
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)

immune system
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:185793


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory