Phenotypes Associated with This Genotype

Genotype
MGI:5431229

• Allelic Composition: Ts(17¹⁶)65Dn/0
• Genetic Background: involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cardiovascular abnormalities in Ts(17¹⁶)65Dn/0 mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:185269 )

cardiovascular system

retroesophageal right subclavian artery ( J:185269 )

• aberrant right subclavian artery arising from the distal part of the aortic arch

abnormal heart morphology ( J:185269 )

• great vessel and cardiac malformation in 1 of 18 mice that died postnatally

ventricular septal defect ( J:185269 )

• 1 in 18 newborns exhibit an upper communication of the ventricles, indication a septation defect of the ventricles

decreased heart rate ( J:185269 )

abnormal heart electrocardiography waveform feature ( J:185269 )

• flecainide-treated mice exhibit a specific electrophysiologic signature as compare to wild-type mice

prolonged RR interval ( J:185269 )

prolonged PR interval ( J:185269 )

decreased P wave amplitude ( J:185269 )

• in the frontal plane

abnormal QRS complex ( J:185269 )

• fragmented time-course with decreased S wave amplitude

decreased QRS amplitude ( J:185269 )

prolonged QRS complex duration ( J:185269 )

prolonged QT interval ( J:185269 )

• larger QT and QTc