Phenotypes for Pkd2 Tg(Pkhd1-cre)1Igr MGI:5430910 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pkd2^tm3Som/Pkd2^tm3Som Tg(Pkhd1-cre)1Igr/?
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2^tm3Som mutation (0 available); any Pkd2 mutation (84 available)
Tg(Pkhd1-cre)1Igr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitotic spindle morphology ( J:185863 )

• loss of orientation of cell division to the lumen of the medullary collecting ducts of the kidney starts to develop after tubules begin to dilate

• no significant change in orientation of cell division to the lumen of the collecting ducts of the kidney at 3 days of age

renal/urinary system

dilated kidney collecting duct ( J:185863 )

• cystic dilation of collecting duct segments beginning at 8-10 days of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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