Phenotypes Associated with This Genotype

Genotype
MGI:5430442

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Notch2)Ryn}/Gt(ROSA)26Sor⁺; Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:185844 )

• mice die shortly after birth

renal/urinary system

renal glomerulus cyst ( J:185844 )

• multiple

abnormal kidney development ( J:185844 )

• at E14.5, kidneys exhibit a thin cortical nephrogenic zone and poor nephron development

• mice exhibit depletion of nephron progenitors and premature tubule formation

• at E12.5, ectopic tubules are observed dorsal to the poorly branched ureteric bud-derived epithelia

absent metanephric mesenchyme ( J:185844 )

• at E14.5, kidneys lack condensed metanephric mesenchyme around the ureteric buds in the cortex and contain few Pax2+ scattered tubules

abnormal metanephric ureteric bud development ( J:185844 )

• at E14.5, no ureteric bud-derived epithelia are observed in the mutant cortex

abnormal nephrogenic zone morphology ( J:185844 )

• thin cortical nephrogenic zone at E14.5

small kidney ( J:185844 )

• at E14.5

• severe at birth

dilated renal tubule ( J:185844 )

dilated proximal convoluted tubule ( J:185844 )

• some of the dilated tubules are positive for a proximal tubule marker

• however, proximal tubules are not overproduced

impaired branching involved in ureteric bud morphogenesis ( J:185844 )

• at E14.5, ureteric bud branching is impaired

growth/size/body

renal glomerulus cyst ( J:185844 )

• multiple