About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5429705
Allelic
Composition
Rag2tm1.1Cgn/Rag2tm1.1Cgn
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1.1Cgn mutation (2 available); any Rag2 mutation (78 available)
Tg(HLA-DR2)#Lfug mutation (0 available)
Tg(TCROb.1A12)#Lfug mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• clinical manifestations included both classical and non-classical EAE symptoms
• focal inflammatory lesions are seen throughout the central nervous system
• inflammatory infiltrate with variable cellular composition, usually containing neutrophilic granulocytes, activated macrophages and T lymphocytes

behavior/neurological
• seen in all mice with an age of onset ranging from 48 to 102 days

nervous system
• focal inflammatory lesions are seen throughout the central nervous system
• inflammatory infiltrate with variable cellular composition, usually containing neutrophilic granulocytes, activated macrophages and T lymphocytes
• focal demyelinated tissue lesions are seen throughout the central nervous system, including the optic and vestibular nerves

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:134764


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory