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Phenotypes Associated with This Genotype
Genotype
MGI:5429704
Allelic
Composition
Tg(Cd4-CD4)2362Litt/0
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
Genetic
Background
involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-CD4)2362Litt mutation (2 available)
Tg(HLA-DR2)#Lfug mutation (0 available)
Tg(TCROb.1A12)#Lfug mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease
• onset, clinical manifestations and course of disease are highly variable
• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects
• drowsy
• staggering gait

nervous system
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:134764


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory