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Phenotypes Associated with This Genotype
Genotype
MGI:5429520
Allelic
Composition		 Prap1tm1Lex/Prap1tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prap1tm1Lex mutation (2 available); any Prap1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:171883 )
• homozygous mutant mice exhibit an increased mean serum IgG2a response to ovalbumin challenge when compared with that of controls
increased immunoglobulin level ( J:171883 )
• mutants exhibit increased mean serum immunoglobulin levels

hematopoietic system
increased immunoglobulin level ( J:171883 )
• mutants exhibit increased mean serum immunoglobulin levels

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory